Publications

Humphreys, K. (2023). Addiction: A Very Short Introduction. Oxford University Press. Link

Humphreys, K., Shover, C.L. (2023). Twenty-year trends in drug overdose fatalities among older adults in the US. JAMA Psychiatry, 80, 518-520. Link

Knutson, B., & Srirangarajan, T. (2023). Disentangling the skeins of brain. Journal of Cognitive Neuroscience, 35, 383-387. Link

MacNiven, K.H., Mortazavi, L., Knutson, B. (2023). Blunted neurobehavioral loss anticipation predicts relapse to stimulant use. Biological Psychiatry, In Press. Link

Humphreys, K., Shover, C. L., Andrews, C. M., Bohnert, A. S., Brandeau, M. L., Caulkins, J. P., … & Timko, C. (2022). Responding to the opioid crisis in North America and beyond: recommendations of the Stanford–Lancet Commission. The Lancet, 399(10324), 555-604. Link

Lim, T. Y., Stringfellow, E. J., Stafford, C. A., DiGennaro, C., Homer, J. B., Wakeland, W., … & Jalali, M. S. (2022). Modeling the evolution of the US opioid crisis for national policy development. Proceedings of the National Academy of Sciences, 119(23), e2115714119. Link

Pomrenze, M. B., Pinto, D. F. C., Neumann, P. A., Llorach, P., Tucciarone, J. M., Morishita, W., … & Malenka, R. C. (2022). Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal. Neuron, 110, 4125-4143. Link

Tisdall, L., MacNiven, K. H., Padula, C. B., Leong, J. K., & Knutson, B. (2022). Brain tract structure predicts relapse to stimulant drug use. Proceedings of the National Academy of Sciences, 119, e2116703119. Link

De Gregorio, D., Aguilar-Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2021). Hallucinogens in mental health: Preclinical and clinical Studies on LSD, Psilocybin, MDMA, and Ketamine. Journal of Neuroscience, 41(5), 891-900. Link

Giardino, W. J., & Pomrenze, M. B. (2021). Extended amygdala neuropeptide circuitry of emotional arousal: Waking up on the wrong side of the bed nuclei of stria terminalis. Frontiers in Behavioral Neuroscience, 15, 613025. Link

Smith, M. L., Asada, N., & Malenka, R. C. (2021). Anterior cingulate inputs to nucleus accumbens control the social transfer of pain and analgesia. Science, 371, 153-159. Link

Sosa, M., & Giocomo, L. M. (2021). Navigating for reward. Nature Reviews Neuroscience, 22, 472-487. Link

Srirangarajan, T., Mortazavi, L., Bortolini, T., Moll, J., & Knutson, B. (2021). Multi‐band FMRI compromises detection of mesolimbic reward responses. NeuroImage, 244, 118617. Link

Stallen, M., Borg, N., Knutson, B. (2021). Brain activity foreshadows stock price dynamics. Journal of Neuroscience. 41, 3266-3274. Link

Heifets, B. D., & Malenka, R. C. (2020). Better living through chemistry: MDMA’s prosocial mechanism as a starting point for improved therapeutics. Neuropsychopharmacology. 46, 261. Link

Keyes, P. C., Adams, E. L., Chen, Z., Bi, L., Nachtrab, G., Wang, V. J., … & Chen, X. (2020). Orchestrating opiate-associated memories in thalamic circuits. Neuron. 110, 3406.  Link

Kiang, M. V., Humphreys, K., Cullen, M. R., & Basu, S. (2020). Opioid prescribing patterns among medical providers in the United States, 2003-17: retrospective, observational study. BMJ, 368. I6968. Link

MacCoun, R. J. (2020). Balancing compassion, accountability, and causal clarity. Addiction. 115, 2209-2210. Link

MacNiven, K. H., Leong, J. K., & Knutson, B. (2020). Medial forebrain bundle structure is linked to human impulsivity. Science Advances, 6, eaba4788.  Link

Steinberg EE, Gore F, Heifets BD, Taylor MD, Norville ZC, Beier KT, Földy C, Lerner TN, Luo L, Deisseroth K, Malenka RC. (2020) Amygdala-midbrain connections modulate appetitive and aversive learning. Neuron. 106, 1026-1043. Link

Wu, H., Adler, S., Azagury, D. E., Bohon, C., Safer, D. L., Barbosa, D. A., … Halpern, C. H. (2020). Brain-responsive neurostimulation for loss of control eating: Early feasibility study. Neurosurgery. 87, 1277-1288. Link

Beier, K.T., Gao, X.J., Xie, S., DeLoach, K.E., Malenka, R.C., Luo, L. (2019). Topological organization of ventral tegmental area connectivity revealed by viral-genetic dissection of input-output relations. Cell Reports, 26,159-167. Link

Butler, W.N., Hardcastle, K., Giocomo, L.M. (2019). Remembered reward locations restructure entorhinal spatial maps. Science, 363, 1447-1452. Link

Feagin, T.A., Maganzini, N., Soh, H.T. (2019). Strategies for creating structure-switching aptamers. ACS Sensors, 3, 1611-1615. Link

Humphreys, K. (2019). Networking: Translating neuroscience to public policy, Neuron, 103, 6, 964-966. Link, Video

Humphreys, K., Saitz, R. (2019). Should physicians recommend replacing opioids with cannabis? JAMA, 321, 639-640. Link

Humphreys, K. (2019). Evaluating dynamic impacts of abuse-deterrent prescription opioid formulations. Addiction, 114, 400-401. Link

Lembke, A., Humphreys, K., Newmark, J. (2019). Weighing the risks and benefits of chronic opioid therapy. Indian Journal of Clinical Practice, 29, 809-817. Link

Raheemullah, A., Lembke, A. (2019). Initiating opioid agonist treatment for opioid use disorder in the inpatient setting: A teachable moment. JAMA Internal Medicine, 179, 427-428. Link

Shover, C.L., Davis, C.S., Gordon, S.C., Humphreys, K. (2019). Association between medical cannabis laws and opioid overdose mortality has reversed over time. PNAS, 116, 12624-12626. Link

Shover, C.L., Humphreys, K. (2019). Six policy lessons relevant to cannabis. American Journal of Drug and Alcohol Abuse. 45, 698-706. Link

Andrews, C.M., Grogan, C.M., Smith, B.T., Abraham, A.J., Pollack, H.A., Humphreys, K., Westlake, M.A., Friedmann, P. (2018). Medicaid Benefits for Addiction Treatment Expanded after Implementation of the Affordable Care Act. Health Affairs ,37(8), 1216-1222. Learn More

Aggarwal, A.K., Lembke, A. (2018). Perioperative Considerations for the Patient with Opioid Use Disorder on Buprenorphine, Methadone, or Naltrexone Maintenance Therapy. Anesthesiology ,36(3), 345-359. Learn More

Beier, K., Kim, C., Hoerbelt, P., Hung, L.W., Heifets, B., DeLoach, K., Mosca, T., Neuner, S., Deisseroth, K., Luo, L., Malenka, R.C. (2018). A Critical Role for the Globus Pallidus in Cocaine-Triggered Plasticity Revealed By Rabies Activity Screen. Biological Psychiatry. Learn More

Barrientos, C., Knowland, D., Wu, M.M.J., Lilascharoen, V., Huang, K.W., Malenka, R.C., Lim, B.K. (2018). Cocaine-Induced Structural Plasticity in Input Regions to Distinct Cell Types in Nucleus Accumbens. Biological Psychiatry. Learn More

Butler, J.M., Becker, W.C., Humphreys, K. (2018). Big Data and the Opioid Crisis: Balancing Patient Privacy with Public Health. The Journal of Law, Medicine & Ethics ,46(2), 440-453. Learn More

Caputi, T.L., Humphreys, K. (2018). Medical Marijuana Users are More Likely to Use Prescription Drugs Medically and Non-medically. Journal of Addiction Medicine ,12(4), 295-299. Learn More

Chumin, E.J., Goni, J., Halcomb, M.E., Durazzo, T.C., Dzemidzic, M., Yoder, K.K. (2018). Differences in White Matter Microstructure and Connectivity in Nontreatment-Seeking Individuals with Alcohol Use Disorder. Alcoholism: Clinical and Experimental Research ,42(5), 889-896. Learn More

Darnall, B.D., Humphreys, K. (2018). An Experimental Method for Assessing whether Marijuana Use Reduces Opioid Use in Patients with Chronic Pain. Addiction. Learn More

Durazzo, T.C., Meyerhoff, D.J., Yoder, K.K. (2018). Cigarette Smoking is Associated with Cortical Thinning in Anterior Frontal Regions, Insula and regions Showing Atrophy in Early Alzheimer’s Disease. Drug and Alcohol Dependence ,192, 277-284. Learn More

Frakt, A.B., Carroll, A.E., Pollack, H.A., Humphreys, K. (2018). The Rewards and Challenges of Writing for a Mass Media Audience. Health Services Research. Learn More

Glantz, S.A., Halpern-Felsher, B., Spinger, M.L. (2018). Marijuana, Secondhand Smoke, and Social Acceptibility. JAMA Internal Medicine ,178(1), 13-14. Learn More

Goldstein, R.L., Carlson, J.L., Halpern-Felsher, B. (2018). Contraception for Adolescents and Young Adults in the Inpatient Setting: The Providers’ Perspective. Hospital Pediatrics. Learn More

Goldstein, R.L., Halpern-Felsher, B. (2018). Adolescent Oral Sex and Condom Use: How Much Should We Worry and What Can We Do? Journal of Adolescent Health ,62(4), 363-364. Learn More

Haffajee, R. L., MacCoun, R. J., & Mello, M. M. (2018). Behind Schedule—Reconciling Federal and State Marijuana Policy. New England Journal of Medicine ,379, 501-504. Learn More

Hall, W., West, R., Marsden, J., Humphreys, K., Neale, J., Petry, N. (2018). It is Premature to Expand Access to Medicinal Cannabis in Hopes of Solving the US Opioid Crisis. Addiction. Learn More

Hall, W., West, R., Marsden, J., Humphreys, K., Neale, J., Petry, N. (2018). The Need for More Consistent Evidential Standards in Cannabis Policy Evaluations. Addiction ,113(6), 987-988. Learn More

Ho, A.L., Salib, A.M.N., Pendharkar, A.V., Sussman, E.S., Giardino, W.J., Halpern, C.H. (2018). The Nucleus Accumbens and Alcoholism: A Target for Deep Brain Stimulation. Journal of Neurosurgery ,45(2). Learn More

Humphreys, K. (2018). Evaluating Dynamic Impacts of Abuse-Deterrent Prescription Opioids Formulations. Addiction. Learn More

Humphreys, K. (2018). Of Moral Judgments and Sexual Addictions. Addiction ,113(3), 387-388. Learn More

Humphreys, K. (2018). How Medicaid Can Strengthen the National Response to the Opioid Epidemic. American Journal of Public Health ,108(5), 589-590. Learn More

Humphreys, K. (2018). Reconciling the Present and the Future in Opioid Prescription Policy: An Ethical Dilemma Pain Medicine. Learn More

Humphreys, K., Bickel, W.K. (2018). Toward a Neuroscience of Long-term Recovery From Addiction. JAMA Psychiatry. Learn More

Humphreys, K., Caulkins, J.P., Felbab-Brown, V. (2018). Opioids of the Masses: Stopping an American Epidemic from Going Global. Foreign Affairs ,97(118). Learn More

Humphreys, K., Darke, S., Marsden, J., West, R. (2018). Extending Addiction’s Conflict of Interest Policy to Cover the Emerging Cannabis Industry. Addiction ,113(2), 205. Learn More

Humphreys, K., Williams, L.M. (2018). What Can Treatment Research Offer General Practice? The Lancet Psychiatry ,5(4), 295-297. Learn More

Knutson, B., Genevsky, A. (2018). Neuroforecasting Aggregate Choice. Current Directions in Psychological Science. Learn More

Lembke, A. (2018). Why Addiction Should Be Considered a Disease. The Judges’ Journal ,57(1), 4-8. Learn More

Lembke, A., Humphreys, K. (2018). The Opioid Epidemic as a Watershed Moment for Physician Training in Addiction Medicine. Academic Psychiatry ,42(2), 269-272. Learn More

Lembke, A., Ottestad, E., Schmiesing, C. (2018). Patients Maintained on Buprenorphine for Opioid Use Disorder Should Continue Buprenorphine through the Perioperative Period. Pain Medicine. Learn More

Lembke, A., Papac, J., Humphreys, K. (2018). Our other Prescription Drug Problem. New England Journal of Medicine ,378(8), 693-695. Learn More

Leong, J.K., MacNiven, K.H., Samanez-Larkin, G.R., Knutson, B. (2018). Distinct Neural Circuits Support Incentivized Inhibition. NeuroImage. Learn More

MacCoun, R.J., Mello, M.M., Haffajee, R.L. (2018). Behind Schedule – Reconciling Federal and State Marijuana Policy. New England Journal of Medicine. Learn More

MacCoun, R.J. (2018). Multiple Gateways. Addiction. Learn More

MacNiven, K. H., Jensen, E. D., Borg, N., Padula, C., Humphreys, K., Knutson, B. (2018). Association of Neural Responses to Drug Cue with Subsequent Relapse to Stimulant Use. JAMA Network Open ,1(8):e186466. Learn More

Mallory, C. S., Hardcastle, K., Bant, J. S., Giocomo, L. M. (2018). Grid Scale Drives the Scale and Long-term Stability of Place Maps. Nature Neuroscience ,21(2), 270. Learn More

McKelvey, K., Halpern-Felsher, B. (2018). Youth Say Flavored E-Cigarette Ads are for Them. Journal of Adolescent Health ,62(2), 136-137. Learn More

McKelvey, K., Halpern-Felsher, B., Lazaro, A. (2018). Youth-Ascribed Cigarette Pack Color Meaning: Correct Perceptions of Green Menthol Flavor Color, Yet Confusion Over Other Colors. Journal of Adolescent Health ,62(2), 137. Learn More

Meyerhoff, D.J., Murray, D.E., Durazzo, T.C., Pennington, D.L. (2018). Brain GABA and Glutamate Concentrations Following Chronic Gabapentin Administration: A Convenience Sample Studied During Early Abstinence from Alcohol. Frontiers in Psychiatry. Learn More

Murray, D.E., Durazzo, T.C., Schmidt, T.P., Murray, T.A., Abe, C., Guydish, Joseph, Meyerhoff, D.J. (2018) Regional Cerebral Blood Flow in Opiate Dependence Relates to Substance Use and Neuropsychological Performance. Addiction Biology. 23(2), 781-795 Learn More

Pitt, A., Humphreys, K., Brandeau, M. (2018). Modeling Public Policy Responses to the Opioid Epidemic. American Journal of Public Health ,108(10), 1394-1400. Learn More

Salib, A.M.N., Ho, A.L., Sussman, E.S., Pendharkar, A.V., Halpern, C.H. (2018). Neuromodulatory Treatments for Alcohol Use Disorder: A Review. Brain Sciences ,8(6), 95. Learn More

Smith, B.T., Seaton, K., Andrews, C., Grogan, C.M., Abraham, A., Pollack, H., Friedmann, P., Humphreys, K. (2018). Benefit Requirements for Substance Use Disorder Treatment in State Health Insurance Exchanges. The American Journal of Drug and Alcohol Abuse ,44(4), 426-430. Learn More

Wu, H., Miller, K. J., Blumenfeld, Z., Williams, N. R., Ravikumar, V., Lee, K. E., Kakusa, B., Sacchet, M. D., Wintermark, M., Christoffel, D. J., Rutt, B. K., Bronte-Stewart, H., Knutson, B., Malenka, R. C., Halpern, C. H. (2018). Closing the Loop on Impulsivity Via Nucleus Accumbens Delta Band Activity in Mice and Man. Proceedings of the National Academy of Sciences. Learn More

Xiaowei, Z., Durazzo, T.C., Meyerhoff, D.J. (2018). Regional Brain Volume Changes in Alcohol-Dependent Individuals during Short-Term and Long-Term Abstinence. Alcoholism: Clinical and Experimental Research ,42(6), 1062-1072. Learn More

Young, S.D., Zheng, K., Chu, L.F., Humphreys, K. (2018). Internet Searches for Opioids Predict Future Emergency Department Heroin Admissions. Drug and Alcohol Dependence. Learn More

Zhu, y., Nachtrab, G., Keyes, P.C., Allen, W.E., Luo, L., Chen, X. (2018). Dynamic Salience Processing in Paraventricular Thalamus Gates Associative Learning. Science ,362(6413), 423-429. Learn More

Zou, X., Durazzo, T.C., Meyerhoff, D.J. (2018). Regional Brain Volume Changes in Alcohol-Dependent Individuals During Short-Term and Long-Term Abstinence. Alcoholism: Clinical and Experimental Research ,42(6), 1062-1072. Learn More

Beier, K. T., Kim, C. K., Hoerbelt, P., Hung, L. W., Heifets, B. D., DeLoach, K. E., Mosca, T. J., Neuner, S., Deisseroth, K., Luo, L. & Malenka, R. C. (2017). Rabies screen reveals GPe control of cocaine-triggered Plasticity. Nature. 549, 345-350. Link

Buchel, C., Peters, J., … Knutson, B., and the IMAGEN Consortium (2017). Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents. Nature Communications, 8(14140). Link

Friedmann, P. D., Andrews, C. M., & Humphreys, K. (2017). How ACA repeal would worsen the opioid epidemic. New England Journal of Medicine, 376(10), e16. Link

Genevsky, A., Yoon, C., Knutson, B. (2017). When brain beats behavior: Neuroforecasting crowdfunding outcomes. Journal of Neuroscience, 37, 8625-8634. Link

Humphreys, K., Malenka, R. C., Knutson, B., & MacCoun, R. J. (2017). Brains, environments, and policy responses to addiction. Science, 356(6344), 1237-1238. Link

Ferenczi, E. A., Zalocusky, K. A., Liston, C., Grosenick, L., Warden, M. R., Amatya, D., Katovich, K., Mehta, H., Patenaude, B., Ramakrishnan, C., Kalanithi, P., Etkin, A., Knutson, B., Glover, G. H., Deisseroth, K. (2016). Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior. Science ,351, aac9698. Link

Leong, J. K., Pestilli, F., Wu, C. C., Samanez-Larkin, G. R., Knutson, B. (2016). White-matter tract connecting anterior insula to nucleus accumbens correlates with reduced preference for positively skewed gambles. Neuron ,89, 63-69. Link

Zalocusky, K. A., Ramakrishnan, C., Lerner, T. N., Davidson, T. J., Knutson, B., Deisseroth, K. (2016). Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making. Nature ,531, 642-646. Link

Zhu, Y., Wienecke, C.F., Nachtrab, G., Chen, X. (2016). A thalamic input to the nucleus accumbens mediates opiate dependence. Nature ,530(7589), 219. Link

Beier, K. T., Steinberg, E. E., DeLoach, K. E., Xie, S., Miyamichi, K., Schwarz, L., Gao, X. J., Kremer, E. J.,Malenka, R. C. & Luo, L. (2015). Circuit architecture of VTA dopamine neurons revealed by systematic input-output mapping. Cell ,162, 622-634. Link

Caulkins, J. P., Kilmer, B., Kleiman, M. A. R., MacCoun, R. J., Midgette, G., Oglesby, P., Pacula, R. L., & Reuter, P. H. (2015). Considering marijuana legalization: Insights for Vermont and other jurisdictions. Santa Monica, RAND. (monograph). Link

Genevsky, A., Knutson, B. (2015). Neural affective mechanisms predict market-level microlending. Psychological Science ,26, 1411-1422. Link

Knutson, B., Huettel, S.A. (2015). The Risk Matrix. Current Opinion in Behavioral Science ,5, 141-146. Link

Lammel, S., Steinberg, E.E., Foldy, C., Wall, N.R., Beier, K., Luo, L. & Malenka, R.C. Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron ,85, 429-438, 2015. Link

Lerner, T. N., Shilyansky, C., Davidson, T. J., Evans, K. E., Beier, K. T., Zalocusky, K. A., Crow, A. K., Malenka, R. C., Luo, L., Tomer, R. & Deisseroth, K. (2015). Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits. Cell ,162, 635-647. Link

MacCoun, R. J. (2015). Balancing evidence and norms in cultural evolution. Organizational Behavior and Human Decision Processes,129, 93-104. Link

MacCoun, R. J., Mello, M. M. (2015). Half baked — The retail promotion of marijuana edibles. New England Journal of Medicine ,372, 989-991. Link

MacCoun, R. J., & Perlmutter, S. (2015). Hide results to seek the truth. Nature ,526, 187-189. Link

Samanez-Larkin, G. R., Knutson, B. (2015). Decision-making in the ageing brain: Changes in affective and motivational circuits. Nature Reviews Neuroscience ,16, 278–289. Link